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Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects

Figure 6

Model of telomere capping activities influenced by NMD.

Disruption of NMD activity results in higher Stn1 transcript and protein levels (Figure 5). Stn1 promotes capping directly and is thought to oppose telomerase recruitment through interaction with Cdc13. Since telomerase has telomere capping function, Stn1 therefore both promotes and inhibits telomere capping.

Figure 6