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Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects

Figure 3

Genetic interaction strength (GIS) comparison between cdc13-1 and yku70Δ.

Genes that significantly interacted with cdc13-1 or yku70Δ are shown, most genes did not interact and would be placed in the centre of the plot. Genes encoding components of selected protein complexes (or proteins which work closely together towards the same function) are indicated by colour-co-ordinated text and symbols. Genes that interact with both cdc13-1 and yku70Δ are open white circles, those that interact with just one mutation are filled white circles. Different regions of the plot are indicated on the top right and borders between regions are intentionally blurred/overlapping as there are not precise cut-offs. An arbitrary GIS cutoff of +/−0.5 is indicated by the black dashed rectangle. Also see Figure S3 for further analysis of these data.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1001362.g003