The Toll-Like Receptor Gene Family Is Integrated into Human DNA Damage and p53 Networks
Figure 3
Induced TLR expression in primary human T-lymphocytes obtained from the same subjects on different days.
TLR gene expression assessed by real time-PCR was measured in PHA-stimulated lymphocytes from 2 volunteers who were sampled twice, separated by 4 months, in a blind study as indicated in the figures (i.e., 12-2009 and 04-2010). The cells were exposed to DNA stressors or nutlin. Presented is the mRNA fold-change compared to untreated cells for patients BS#19 (A) and BS#20 (B).