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A Novel Unstable Duplication Upstream of HAS2 Predisposes to a Breed-Defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs

Figure 5

Expression analysis reveals a trend of increased HAS2 and HAS2as expression with copy number.

Expression levels were measured in dermal fibroblasts that were cultured from individual Shar-Pei skin biopsies. The individual with the lowest copy number (CNV = 5) was used to calibrate each assay.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1001332.g005