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A Novel Unstable Duplication Upstream of HAS2 Predisposes to a Breed-Defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs

Figure 4

The relationship between copy number estimate and susceptibility to Familial Shar-Pei Fever.

A significant correlation (p = <0.0001, Mann Whitney test) was seen when the meatmouth copy number in unaffected Shar-Pei (n = 16, H+) and individuals affected by FSF (n = 28, FSF+ and FSF+ A) were compared. Based on this limited sample size, most dogs with more than six copies had fever whereas most dogs with less than four copies did not.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1001332.g004