Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk
Figure 7
Model showing how 9p21 polymorphisms influence ANRIL isoform production to modulate INK4/ARF gene transcription.
PcG complexes (e.g. PRC-1) are targeted to the coding INK4/ARF locus by ANRIL, and modulate its repression. Nascent ANRIL transcripts are spliced to produce circular ANRIL species (cANRIL). Causal variants in the ASVD risk interval modulate ANRIL transcription or splicing to influence INK4/ARF expression. See discussion for further description.