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The Complex Genetic Architecture of the Metabolome

Figure 9

Heatmap of gene–gene LD for all hotspot genes.

The average maximum SNP-SNP r2 (see Materials and Methods) between each of the 176 hotspot genes (y-axis) and the genome (x-axis) is plotted. Not all 31,505 genes are shown on the x-axis: only those with average maximum SNP-SNP r2>0.3 are included. Note that, because only selected genes are plotted, the genomic distances in the two axes are not to scale. The horizontal dashes on the right-hand side of the heatmap indicate whether the gene is located within a hotspot identified in Expt. A (red) or Expt. B (blue).

Figure 9