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Characterising and Predicting Haploinsufficiency in the Human Genome

Figure 6

Enrichment of predicted HI genes in orthologs of mouse haploinsufficient genes and mouse haplolethal genes.

This plot shows the fold of enrichment of predicted HI genes in human orthologs of mouse haploinsufficient genes (black solid line) and mouse haplolethal genes (black dashed line) relative to the genome average as a function of the proportion of top predictions labeled as being haploinsufficient. The two lines in grey show the transformed p values of the corresponding Fishers' exact test. The horizontal dashed line marks the p value of 0.05.

Figure 6

doi: https://doi.org/10.1371/journal.pgen.1001154.g006