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Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits

Figure 1

Web-based accrual of genotype and phenotype data via a personal genetic information service.

(A) Individual participant signs up for service via web; (B) Participant receives sample collection kit; (C) Participant consents, via web, to use of anonymized genotype and survey responses for research; (D) Participant sends saliva sample to contracted lab; (E) Participant logs on to service web site with option to respond to one or more surveys, prior to having access to personal genetic data; (F) Laboratory processes sample, generating data for single nucleotide polymorphisms (SNPs); (G) Encrypted genotype data transferred from laboratory to secure server; (H) Participant logs on to service web site with option to access personal genetic data (both raw genotypes and customized reports); (I) Participant logs on and has the option to respond to one or more surveys; (J) New genetic reports posted, new surveys posted; (K) Genotype data and survey responses for individuals, coded and stripped of individually identifying information, are transferred to research team. Shaded boxes indicate participant actions; clear boxes indicate lab or service actions. Dashed boxes indicate optional participant actions within framework of service access.

Figure 1