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Phosphorylation of the Conserved Transcription Factor ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in Caenorhabditis elegans

Figure 9

Model for the function of ATF-7 in C. elegans innate immunity.

(A) Repression of PMK-1–regulated immune effector gene expression by ATF-7 in the absence of PMK-1 activation. (B) Activation of basal and pathogen-induced immune effector gene expression by PMK-1 phosphorylation of ATF-7, which switches ATF-7 from a repressor to an activator of transcription.

Figure 9

doi: https://doi.org/10.1371/journal.pgen.1000892.g009