Advertisement

< Back to Article

Phosphorylation of the Conserved Transcription Factor ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in Caenorhabditis elegans

Figure 7

Requirement for ATF-7 in resistance to other bacterial pathogens.

(A) Pathogenesis assay of L4 larval stage wild-type worms; atf-7(qd22 qd130) and pmk-1(km25) mutant animals; and atf-7(qd22 qd130); pmk-1(km25) double mutant animals, on S. marcescens Db10. All strains carry the agIs219 transgene. The difference in susceptibility between atf-7(qd22 qd130) mutant animals and wild-type worms is significant (p<0.0001). (B) Pathogenesis assay of L4 larval stage wild-type worms; atf-7(qd22 qd130) and pmk-1(km25) mutant animals; and atf-7(qd22 qd130); pmk-1(km25) double mutant animals, on E. faecalis MMH594. All strains carry the agIs219 transgene. The difference in susceptibility between pmk-1(km25) mutant animals and atf-7(qd22 qd130); pmk-1(km25) double mutant animals is significant (p<0.0001). There is no difference in susceptibility between atf-7(qd22 qd130) mutant animals and wild-type worms (p>0.9).

Figure 7

doi: https://doi.org/10.1371/journal.pgen.1000892.g007