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Phosphorylation of the Conserved Transcription Factor ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in Caenorhabditis elegans

Figure 2

Mutant alleles of C. elegans atf-7, an ortholog of the mammalian ATF2/ATF7/CREB5 family of bZIP transcription factors.

(A) Identification of mutations in the C. elegans atf-7 gene. Changes shown in amino acid residues are in reference to the coding region of gene model C07G2.2a. (B) Sequence alignment comparing the DNA binding domains of C. elegans ATF-7 and human ATF-2. (C) Phylogenetic analysis grouping C. elegans ATF-7 with the mammalian ATF2/ATF7/CREB5 family of bZIP transcription factors.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1000892.g002