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Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

Figure 1

Linkage disequilibrium and association at loci reaching genome-wide significance for primary tooth development in meta-analysis of NFBC1966 and ALSPAC.

(A) KCNJ2 gene region for time to first tooth eruption. (B) EDA gene region for time to first tooth. (C) MSRB3 gene region for time to first tooth. (D) IGF2BP1 gene region for number of teeth at 12 months (SNP with high P at 44000 kb is that near HOXB2, rs6504340). Note: This is a gene-rich region, so most genes are omitted to simplify the plot. (E) RAD51L1 gene region for number of teeth at 12 months. -log10 p-value is plotted against genomic position (NCBI build 36). Most significant SNP in each region is plotted in blue, r2 with top SNP is colour coded red (0.8 – 1.0), orange (0.5 – 0.8), yellow (0.2 – 0.5), and white <0.2. Gene annotations are based on Genome Browser (RefSeq Genes) and arrows represent direction of transcription. Recombination rate is estimated by LDhat using HapMap CEU sample. All r2 values are calculated in NFBC1966.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1000856.g001