Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution
Figure 3
Conservation of a novel TA system.
(A) Genomic regions of Rv0909-Rv0910 TA module orthologs (orange) across diverse mycobacteria showing conservation of toxin and cognate antitoxin genes as well as surrounding genomic context, as indicated by color coding of orthologs across species. (B) M. smegmatis Rv0909-0910 orthologs encode a functional TA system. M. smegmatis cells expressing MSEMG_5634 alone or MSMEG_5634-5635 under the control of the inducible acetamidase promoter were serially diluted and plated on solid media with (right panel) or without (left panel) 0.2% acetamide. (A) adapted from the tree-browser function in MicrobesOnline [60].