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The Origin Recognition Complex Interacts with a Subset of Metabolic Genes Tightly Linked to Origins of Replication

Figure 6

ORF–ORC sites are enriched downstream of replication origins.

The schematic at the top of the figure shows how distances to the nearest 5′ and 3′ ARSs were calculated for every ORF in the genome (dubious ORFs were omitted from this analysis). (A) The ORF–ORC set was enriched for genes located within 10 Kb of the nearest upstream origin compared to all ORFs. (B) Median distances to nearest 5′ and 3′ origins are plotted for several classes of ORFs, categorized by expression level or functional process. The ORF–ORC set was the only gene category closely associated with upstream origins.

Figure 6