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The Origin Recognition Complex Interacts with a Subset of Metabolic Genes Tightly Linked to Origins of Replication

Figure 4

Origins of replication could combine orc2-1-resistance with high firing efficiency.

Unlike HMR-E, orc2-1-resistant replication origin ARS1005 could fire with high efficiency at its endogenous chromosomal location. Like HMR-E, ARS1005 was resistant to orc2-1 for firing efficiency, while neighboring origin ARS1006 that was orc2-1-sensitive for ORC binding was also orc2-1–sensitive for firing.

Figure 4