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The Drosophila foraging Gene Mediates Adult Plasticity and Gene–Environment Interactions in Behaviour, Metabolites, and Gene Expression in Response to Food Deprivation

Figure 6

Insulin pathway genes interact with foraging alleles in expression and in food-leaving behaviour.

Flies carrying different for alleles crossed to mutants of the positive regulators (A) InR and (B) Dp110 (dashed curves) show almost none of the normal food-deprived rover-sitter food-leaving difference (compare to Figure 1 and solid balancer curves in this figure). In these quantitative complementation crosses, the food leaving behaviour of FD for;mutant transheterozygotes is compared to the FD for;Balancer transheterozygote controls. The difference in food leaving between the control balancer and mutant cross depends significantly on foraging allele, demonstrating interaction between the mutant gene and for. p(Interaction) = 0.012 (InR), p = 0.046 (Dp110). Data is arcsine transformed means±1 standard error for trials on n days (n = 11 for InR and Dp110). Behaviour assays were performed on FD flies as described in Figure 1 and Methods. Full ANOVA statistics are in Table S5.

Figure 6

doi: https://doi.org/10.1371/journal.pgen.1000609.g006