The Drosophila foraging Gene Mediates Adult Plasticity and Gene–Environment Interactions in Behaviour, Metabolites, and Gene Expression in Response to Food Deprivation
Individual genes involved in energy metabolism have significant for×food interactions (Int) with GEI I<0 for catabolism and I>0 for anabolism (top row), while two functional groups of genes involved in catabolism and anabolism have group-level interactions in the same pattern (bottom row). (A) Glycogen phosphorylase (GlyP), a key enzyme in glycogen breakdown; q(Int) = 5.68×10−5, I<0. (B) eukaryotic translation initiation factor 4A (eIF-4A), part of the translation initiation complex; q(Int) = 0.0041, I>0. (C) Group-level ANOVA (see Methods) for Gene Ontology (GO) group 5975, carbohydrate metabolism; q(Int) = 0.032, I<0. (D) GO group 6412, protein biosynthesis; q(Int) = 0.0023, I>0 (Table S3 has GO group ANOVA tables). Error bars are ±1 s.e.m. There is a significant background (BG)×food interaction in (d) (q = 8.75×10−7); for (A–C) there is no BG×food interaction; there is a BG main effect in (A,C,D).