CLRN1 Is Nonessential in the Mouse Retina but Is Required for Cochlear Hair Cell Development
Figure 6
Histological analysis of Clrn1 KO retinas at 9 months of age.
(A–C) Compared to WT animals (A), outer retinal histology appears normal in heterozygous (B) and homozygous (C) Clrn1 KO mice. (D–F) Similarly, the inner retina of the Clrn1 KO (+/−,−/−) animals is indistinguishable from the WT animal (D). (G–L) When compared to WT (+/+) animals (G and J) at lower magnification, gross retinal structure seems unperturbed by the lack of Clrn1 expression (H,I,K,L) in either mid-peripheral retina (G–I) or central retina (J–L) immediately adjacent to the optic nerve head (asterisks). Scale bar = 50 µm. ONL = outer nuclear layer, IS = photoreceptor inner segments, OS = photoreceptor outer segments, and RPE = retinal pigmented epithelium.