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General Rules for Optimal Codon Choice

Figure 5

Optimal codon identities in codon families with six or three members.

Bacteria were divided based on their intergenic GC contents. For each codon family in each intergenic GC content grouping, the small bar graph depicts the percentage of the bacterial groups for which each of the possible codons is optimal (has the most significant (p≤0.05/n, where n is the number of codons in the codon family) correlation with levels of codon bias, as measured using both Nc and Nc'). Cases in which no optimal codon was found using either Nc or Nc', or in which different optimal codons were identified using the two measures are counted as “none.” The graphs are all scaled to size.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1000556.g005