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Genome-Wide uH2A Localization Analysis Highlights Bmi1-Dependent Deposition of the Mark at Repressed Genes

Figure 3

Promoter and non-promoter peaks of Bmi1-dependent uH2A are distinct.

(A) Proportion of promoter uH2A peaks (n = 671) (left bar) and non-promoter uH2A peaks (n = 15735)(right bar) which overlap with H3K4/H3K27 methylation peaks. No K4/No K27, purple; both H3K4me3 and H3K27me3 (Bivalent), green; H3K27me3 only, blue; H3K4me3 only, red. (B) Box plot representation of peak tag density distribution for promoter and non-promoter uH2A peaks. Red lines indicate median values. P value derived from Wilcoxon signed-rank test. (C) Box plot representation of peak tag density distribution for promoter (+) and non-promoter (−) uH2A peaks further sub-divided by H3K4me3/H3K27me3 co-localization. No K4/No K27, purple; both H3K4me3 and H3K27me3 (Bivalent), green; H3K27me3 only, blue; H3K4me3 only, red. White lines indicate median values. P value derived from Wilcoxon signed-rank test.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1000506.g003