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Genome-Wide uH2A Localization Analysis Highlights Bmi1-Dependent Deposition of the Mark at Repressed Genes

Figure 2

Bmi1-dependent promoter uH2A enrichment at a sub-set of gene promoters.

(A) Bmi1-dependent tag density at selected gene promoters that contain peaks defined by the TIROE algorithm. Red arrow indicates the start and direction of transcription. (B) ChIP-qPCR validation of uH2A peaks (blue bars) and Bmi1 enrichment (red bars) was carried out in WT and Bmi1 null MEF cells. Enrichment was normalized to input control and data is presented as log2 value of WT versus Bmi1 null.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1000506.g002