Modulated Modularity Clustering as an Exploratory Tool for Functional Genomic Inference
(A) Representation of the NK cell mediated cytotoxicity KEGG pathway. Genes in Module 5 associated with HDL-C variation are colored orange. (B) Relevance network representation of Module 5 after enforcing an absolute correlation threshold of 0.5. (C) Bar graphs of cell-specific expression patterns restricted to derivatives of whole blood. Grey bars indicate relative cell-specific expression levels across all 673 genes associated with HDL-C. Blue bars consider only the genes in Module 5.