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Modulated Modularity Clustering as an Exploratory Tool for Functional Genomic Inference

Figure 7

Illustration of module-specific enrichment of pathways and tissues.

(A) Representation of the NK cell mediated cytotoxicity KEGG pathway. Genes in Module 5 associated with HDL-C variation are colored orange. (B) Relevance network representation of Module 5 after enforcing an absolute correlation threshold of 0.5. (C) Bar graphs of cell-specific expression patterns restricted to derivatives of whole blood. Grey bars indicate relative cell-specific expression levels across all 673 genes associated with HDL-C. Blue bars consider only the genes in Module 5.

Figure 7

doi: https://doi.org/10.1371/journal.pgen.1000479.g007