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Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers

Figure 9

Genome-wide power of the Affymetrix 500 k chip estimated by different methods.

We use the HapMap CEU reference data. We assume a multiplicative disease model with relative risk 1.2, disease prevalence .01, and a uniform distribution of causal SNPs over common SNPs (MAF≄.05). We use the significance threshold of .05.

Figure 9

doi: https://doi.org/10.1371/journal.pgen.1000456.g009