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Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers

Figure 8

Effect of window size on SLIDE's performance.

Using the WTCCC T2D case/control chromosome 22 data, we plot the ratios between the corrected p-value and the permutation p-value for varying window sizes for SLIDE. We use the pointwise p-value corresponding to the permutation p-value .05. The window size zero denotes the Bonferroni correction. The dashed lines denote the interval where an accurate methods' estimate will be found more than 95% of the time.

Figure 8

doi: https://doi.org/10.1371/journal.pgen.1000456.g008