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Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers

Figure 7

Effective number of tests of the 2.7 million HapMap SNPs for a simulated dataset.

A dataset of 2,000 cases and 2,000 controls is generated from the HapMap CEU data. Using each method, we estimate the per-marker threshold corresponding to a significance level of .05. The effective number of test is simply .05 divided by the per-marker threshold. The dashed lines denote the interval where an accurate methods' estimate will be found more than 95% of the time.

Figure 7