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Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers

Figure 5

Ratios between corrected p-values and permutation p-values for ten different p-value thresholds.

We use the WTCCC T2D case/control chromosome 22 data. Approximated time is for correcting 10 p-values with respect to 500 K SNPs assuming 100 K permutations. The dashed lines denote the interval where an accurate methods' estimate will be found more than 95% of the time.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1000456.g005