Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers
The probability density function of the asymptotic bivariate MVN is depicted as a grid. The probability mass function of the true distribution is depicted as a histogram. (A) The asymptotic distribution often shows a discrepancy from the true distribution. (The discrepancy is exaggerated in this figure.) (B) After scaling down the asymptotic distribution, the discrepancy is removed.