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Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers

Figure 4

SLIDE's scaling procedure.

The probability density function of the asymptotic bivariate MVN is depicted as a grid. The probability mass function of the true distribution is depicted as a histogram. (A) The asymptotic distribution often shows a discrepancy from the true distribution. (The discrepancy is exaggerated in this figure.) (B) After scaling down the asymptotic distribution, the discrepancy is removed.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1000456.g004