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Rapid and Accurate Multiple Testing Correction and Power Estimation for Millions of Correlated Markers

Figure 2

Probability density function of a bivariate MVN at two markers.

The area outside the rectangle is the critical region. (A) Under the null hypothesis, the MVN is centered at zero. The outside-rectangle probability is the corrected p-value (or the significance level). (B) Under the alternative hypothesis, the MVN is shifted by the non-centrality parameter. The outside-rectangle probability is power.

Figure 2

doi: https://doi.org/10.1371/journal.pgen.1000456.g002