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Capturing the Spectrum of Interaction Effects in Genetic Association Studies by Simulated Evaporative Cooling Network Analysis

Figure 4

Genetic association interaction network (GAIN) for the top 70 SNPs selected by Evaporative Cooling (EC) as most relevant to smallpox vaccine-associated adverse events.

Three nodes and their connections are highlighted: the hub glycogen synthase kinase 3 beta (GSK3B, orange) and the two main effect genes, 5,10-methylenetetrahydrofolate reductase (MTHFR, yellow) and interleukin-4 (IL4, green). Solid edges indicate synergy (positive interaction information (II)) between incident SNPs that results in an increase in information about the phenotype when the two SNPs are considered jointly. Dashed edges between incident SNPs indicate redundancy (negative II) with respect to information about the phenotype.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1000432.g004