Capturing the Spectrum of Interaction Effects in Genetic Association Studies by Simulated Evaporative Cooling Network Analysis
Detection power analysis of 100 simulated replicates of an 8-locus model that combines all genetic models defined in Figure 1.
Each replicate has a population size of 500 cases and 500 controls and the eight functional loci are embedded in 1500 SNPs. Detection frequency is shown for each of the eight functional loci for EC with a cutoff of 50 SNPs compared with forward stepwise penalized logistic regression (StepPLR). The first two simulated loci (X1 and X2) follow the disease model defined in Interaction Model 1, the second two simulated loci (X3 and X4) come from Interaction Model 2 and so on.