A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species
Panel A shows a comparison of the mean shortest path length of the 175 genes in the longevity cohort to the average shortest path length distribution in the Core Network. The histogram shows the distribution of mean shortest path lengths observed in 1,000 sets of 175 genes randomly selected from the 10,430 unique genes present as nodes in the Core Network. The mean shortest path length for all genes is 4.61. By comparison, the mean shortest path length for the 175 longevity genes is 4.15 (vertical red line). The p-value for the significance of this difference is 0.004. Panel B shows path length analysis for interactions among longevity homologs using randomized networks. The mean shortest path length between the 175 longevity protein homologs in the network is 4.15 (vertical red line). The distribution of mean shortest path lengths between these proteins in 100 networks with randomly assigned connections is shown. The peak of the distribution in the randomized networks is 4.73. As none of the values from the permutation distribution was less than 4.15, the p-value for the significance of this difference is <0.01.