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A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species

Figure 1

Node Degree Distributions in Core Network and Longevity Network.

Panel A shows the node degree distribution in unfiltered and Core protein interaction networks. A log-log plot of node degrees in both unfiltered and Core interaction networks appears as a straight line indicating that both are scale free. Black circles represent node degrees of 11,280 proteins in a network of 114,698 interactions. Red circles show the node degree distribution after removal of bait proteins with >87 interactions and prey proteins with >231 interactions. The Core Network contains 70,358 binary interactions among 10,425 unique proteins. Panel B shows the node degree distributions of the Core and longevity networks represented as box plots. The average node degree in the Core Network is 13.5. The average node degree for the 175 longevity proteins is 18.8. Median node degrees (indicated by thick horizontal lines) for the core and longevity networks are respectively 5.0 and 7.0.

Figure 1