An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans
Figure 5
Ventral nerve cord is affected in 4 day old adult G85R animals – fewer and smaller diameter processes and lack of organelles.
A, Number of neuronal processes is mildly reduced. Transverse sections of transgenic animals were prepared and examined by EM, and the number of neuronal processes in the main bundle of the ventral nerve cord was determined. N = 9. (Error bars indicate SEM.) B–E, Representative cross-sections of WTSOD and G85R animals at two levels of magnification, with white dashed lines in B, C denoting the boundaries of the main bundle of processes. The diameter of processes was reduced, and the number of organelles including mitochondria (m) and synaptic vesicles (arrows) was greatly reduced in G85R.