Copy Number Variation of CCL3-like Genes Affects Rate of Progression to Simian-AIDS in Rhesus Macaques (Macaca mulatta)
(A) Scatter plot of post SIV infection survival time (or censor time if animal is alive) by CCL3L copy number. Blue dots represent Chinese-origin rhesus macaques while green dots represent Indian origin. Filled in dots represent animals still alive at time of sampling. Fitted regression curve, p-value and relative-hazard (RH) from Cox proportional hazard model (model 1 in text). (B,C) Boxplots of CCL3L copy-number defining “low” copy number to be fewer than or equal to 8 copies per diploid genome, “intermediate” to be 9 and 14, and “high” to be more than 14 copies or low vs. intermediate+high. D-I) Estimated Kaplan-Meier survival curve for SIV-infected macaques with time measured from date of infection. The black curve represents “low”, the red curve “intermediate” or “intermediate+high”, and the blue curve “high” copy number for KM curves based on all animals (D,E), Indian-origin only (F,G), and Chinese-origin only (H,I). The p-values correspond to Harrington-Fleming tests of equality for survivorship curve using ρ = 0 which is equivalent to a log-rank or Mantel-Haenszel test. Relative-hazard (RH) for equivalent Cox proportional hazard model are also presented.