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The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan

Figure 4

am177 is a missense mutation of osm-3.

(A) A schematic of the OSM-3 protein showing amino acid numbers (below) and four functional regions: the motor (left diagonal lines), neck (shaded), rod (open) and tail (right diagonal lines) [47]. The position of am177 and six previously characterized mutations are shown above with the mutation name and molecular change [47]. (B) The predicted amino acid sequence of OSM-3 (M02B7.1B). The am177 mutation changes codon 329 from AAC (N) to CAC (H), affecting the neck region of the protein.

Figure 4

doi: https://doi.org/10.1371/journal.pgen.1000230.g004