The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan
(A) A schematic of the OSM-3 protein showing amino acid numbers (below) and four functional regions: the motor (left diagonal lines), neck (shaded), rod (open) and tail (right diagonal lines) . The position of am177 and six previously characterized mutations are shown above with the mutation name and molecular change . (B) The predicted amino acid sequence of OSM-3 (M02B7.1B). The am177 mutation changes codon 329 from AAC (N) to CAC (H), affecting the neck region of the protein.