Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays
Experimental validation using a series of mixtures (see Methods A–F) assayed on the Affymetrix GeneChip 5.0, Illumina BeadArray 550 and the Illumina 450S Duo Human BeadChip.
The x-axis shows each individual in the CEU HapMap population, the left y-axis shows the p-value (log scaled), and the right y-axis shows the value of the test statistic. For mixtures A, B, E and F those in the mixture are colored green and those not in the mixture are colored red. For mixtures C and D those individuals who are not in the mixtures are colored red, those individuals who are related to the 1% or 10% individuals in the mixtures are colored orange, those individuals who are related to the 90% or 99% are colored yellow, and those people in the mixture are colored green. In all mixtures, the identification of the presence of a person's genomic DNA was possible.