High-Precision, Whole-Genome Sequencing of Laboratory Strains Facilitates Genetic Studies
A) relA- colonies generate suppressors that engulf the original colonies. 1–4: gradual generation and development of suppressors. B) The yjbM* mutation partially suppresses the relA- growth defect, but these colonies continue to generate suppressor mutations, presumably at genomic loci other than yjbM. 1. relA- yjbM* before other suppressors are generated. 2, 3. relA- yjbM* with new suppressors. 4. relA- with double suppressors (relA- yjbM* ywaC*).