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High-Precision, Whole-Genome Sequencing of Laboratory Strains Facilitates Genetic Studies

Figure 3

Verification of the Solexa results by Sanger sequencing.

A) Selected reads from strain 168 where results from Solexa suggest missense changes with respect to the reference. B) Selected reads from strain 168 where results from Solexa suggest insertions or deletions with respect to the reference. C) Selected reads from 168 and NCIB 3610 where results from Solexa suggest nonsense mutations in the reference sequence. D) Selected reads from JH642 and 168 where results from Solexa suggest nonsense changes in JH642 with respect to 168. In each case, the published reference sequence is indicated first, the Solexa sequence(s) are shown next, and the Sanger sequencing results and corresponding chromatograms are depicted last.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1000139.g003