Identification and Dissection of a Complex DNA Repair Sensitivity Phenotype in Baker's Yeast
Figure 5
Two regions are associated with the 4-NQO-sensitive phenotype.
DNA from pools of forty backcrossed individuals (BK3) either resistant or sensitive to 4-NQO was hybridized to Affymetrix tiling arrays. The difference in intensity values was calculated for every probe that was considered to contain a sequence variant between BY and RM by SNPscanner [51]. The log10 (intensity difference) was plotted along the chromosome and smoothed. Chromosomes that displayed regions where the smoothed value exceeded +/−1 are shown in panels A and B. Panel C is a representative image of the chromosomes that did not show linkage regions.