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Combined Analysis of Murine and Human Microarrays and ChIP Analysis Reveals Genes Associated with the Ability of MYC To Maintain Tumorigenesis

Figure 6

Expression of previously published direct MYC targets was permanently repressed or induced upon MYC inactivation in osteosarcomas.

Murine homologs of directed MYC targets identified from 3 publications [33][35] were retrieved and their expression in the bone tumors upon MYC inactivation and reactivation was examined. Genes scored statistically significant (p<0.01) in the StepMiner analysis were labeled.

Figure 6

doi: https://doi.org/10.1371/journal.pgen.1000090.g006