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Combined Analysis of Murine and Human Microarrays and ChIP Analysis Reveals Genes Associated with the Ability of MYC To Maintain Tumorigenesis

Figure 5

Expression of previously published MYC targets was permanently repressed or induced upon MYC inactivation in osteosarcomas.

MYC targets collected in www.myc-cancer-gene.org were used as a list to filter the microarray data from osteosarcomas upon MYC inactivation and reactivation. Gene expression permanently repressed (PR) or permanently induced (PI) were identified while MYC was inactivated in bone tumors.

Figure 5

doi: https://doi.org/10.1371/journal.pgen.1000090.g005