Advertisement

< Back to Article

Combined Analysis of Murine and Human Microarrays and ChIP Analysis Reveals Genes Associated with the Ability of MYC To Maintain Tumorigenesis

Figure 3

Permanent and reversible changes of gene expression upon MYC inactivation in osteosarcomas identified by the StepMiner algorithm.

Statistically significant changes (p<0.01) with specific patterns are listed here: 1777 probes with expression went up after MYC inactivation and stayed up upon MYC reactivation (the PI group), 1016 probes with expression went down after MYC inactivation and remained down upon MYC reactivation (the PR group), 1148 probes with expression went up after MYC inactivation and went back down upon MYC reactivation (the RI group) and 1167 probes with expression went down after MYC inactivation and went back up upon MYC reactivation (the RR group). Lists of gene names in each group are shown in Table S2. Pie Charts summarizing numbers of genes in each group are shown in supplementary Figure 3.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1000090.g003