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Specificity of the STAT4 Genetic Association for Severe Disease Manifestations of Systemic Lupus Erythematosus

Figure 1

Haploview linkage disequilibrium map of D’ for 67 Sequenom STAT1/STAT4 SNPs in 2278 study subjects.

(A) Green markers are in STAT1 and STAT4 genes as indicated. Four SNPs comprising the top SLE risk haplotype, from allelic and conditional analyses (Table 4 (C)), are circled. (B) Haploview linkage disequilibrium map of D’ for 91 Illumina 550K STAT1/STAT4 extended region SNPs in 3138 study subjects. Green markers are in STAT1 and STAT4 genes as indicated. The top SLE risk SNP rs7574865 from allelic and conditional analyses (Table 4 (A)) is circled.

Figure 1

doi: https://doi.org/10.1371/journal.pgen.1000084.g001