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A Genome-Wide Gene Expression Signature of Environmental Geography in Leukocytes of Moroccan Amazighs

Figure 3

Sex and location effects on methylation patterns.

Two-way clustering of differentially methylated CpG sites at P<0.05 (ANOVA) for the sex effect (A) and for the location effect (B). Sample labels indicate their sex and location (M: male, F: female, E: nomad, SN: rural, and A: urban). There is clear separation of the sexes in (A), and a suggestion of a signature of urban living for a dozen or so genes in (B) highlighted as the Anza-enriched cluster.

Figure 3

doi: https://doi.org/10.1371/journal.pgen.1000052.g003