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Open Access
Peer-reviewed
Research Article
Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets
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Zhidong Tu ,
Contributed equally to this work with: Zhidong Tu, Mark P. Keller
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Mark P. Keller ,
Contributed equally to this work with: Zhidong Tu, Mark P. Keller
Affiliation Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
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Chunsheng Zhang,
Affiliation Merck Research Laboratories, Boston, Massachusetts, United States of America
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Mary E. Rabaglia,
Affiliation Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
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Danielle M. Greenawalt,
Affiliation Merck Research Laboratories, Boston, Massachusetts, United States of America
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Xia Yang,
Affiliation Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
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I-Ming Wang,
Affiliation Merck Research Laboratories, Rahway, New Jersey, United States of America
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Hongyue Dai,
Affiliation Merck Research Laboratories, Boston, Massachusetts, United States of America
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Matthew D. Bruss,
Affiliation Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
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Pek Y. Lum,
Current address: Ayasdi, Palo Alto, California, United States of America
Affiliation Department of Genetics, Rosetta Inpharmatics, Merck, Seattle, Washington, United States of America
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Yun-Ping Zhou,
Affiliation Merck Research Laboratories, Rahway, New Jersey, United States of America
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Daniel M. Kemp,
Affiliation Merck Research Laboratories, Rahway, New Jersey, United States of America
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Christina Kendziorski,
Affiliation Department of Biostatistics and Medical Informatics, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
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Brian S. Yandell,
Affiliation Department of Statistics, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
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Alan D. Attie,
Affiliation Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
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Eric E. Schadt,
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America, Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America, Pacific Biosciences, Menlo Park, California, United States of America
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Jun Zhu
* E-mail: jun.zhu@mssm.edu
Affiliations Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America, Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
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Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets
- Zhidong Tu,
- Mark P. Keller,
- Chunsheng Zhang,
- Mary E. Rabaglia,
- Danielle M. Greenawalt,
- Xia Yang,
- I-Ming Wang,
- Hongyue Dai,
- Matthew D. Bruss,
- Pek Y. Lum
- Published: December 6, 2012
- https://doi.org/10.1371/journal.pgen.1003107