Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum

• Daria Van Tyne ,

  Contributed equally to this work with: Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino

  Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• Daniel J. Park ,

  Contributed equally to this work with: Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino

  Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Stephen F. Schaffner ,

  Contributed equally to this work with: Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino

  Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

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• Daniel E. Neafsey ,

  Contributed equally to this work with: Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino

  Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

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• Elaine Angelino ,

  Contributed equally to this work with: Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino

  Affiliations FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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• Joseph F. Cortese,

  Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

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• Kayla G. Barnes,

  Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• David M. Rosen,

  Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• Amanda K. Lukens,

  Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• Rachel F. Daniels,

  Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Biological and Biomedical Sciences, Harvard University, Cambridge, Massachusetts, United States of America

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• Danny A. Milner Jr.,

  Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• Charles A. Johnson,

  Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

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• Ilya Shlyakhter,

  Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Sharon R. Grossman,

  Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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• Justin S. Becker,

  Affiliation Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Daniel Yamins,

  Affiliation FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Elinor K. Karlsson,

  Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Daouda Ndiaye,

  Affiliation Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal

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• Ousmane Sarr,

  Affiliation Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal

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• Souleymane Mboup,

  Affiliation Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar, Senegal

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• Christian Happi,

  Affiliation Malaria Research Laboratories, College of Medicine, University of Ibadan, Ibadan, Nigeria

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• Nicholas A. Furlotte,

  Affiliation Department of Computer Science and Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America

  ⨯
• Eleazar Eskin,

  Affiliation Department of Computer Science and Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America

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• Hyun Min Kang,

  Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Daniel L. Hartl,

  Affiliation Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Bruce W. Birren,

  Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

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• Roger C. Wiegand,

  Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

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• Eric S. Lander,

  Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

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• Dyann F. Wirth ,

  ¶These authors also contributed equally to this work.

  Affiliations Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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• Sarah K. Volkman ,

  ¶These authors also contributed equally to this work.

  Affiliations Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, School for Health Sciences, Simmons College, Boston, Massachusetts, United States of America

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•  [ ... ],
• Pardis C. Sabeti

  * E-mail: pardis@broadinstitute.org

  ¶These authors also contributed equally to this work.

  Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America, FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America

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