Prevalence of Epistasis in the Evolution of Influenza A Surface Proteins

Open Access

Peer-reviewed

Research Article

Sergey Kryazhimskiy,

Current address: Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America

Affiliation Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Jonathan Dushoff,

Affiliation Department of Biology, McMaster University, Hamilton, Canada
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Georgii A. Bazykin,

Affiliation Institute for Information Transmission Problems (Kharkevich Institute) of the Russian Academy of Sciences, Moscow, Russia
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Joshua B. Plotkin

* E-mail: jplotkin@sas.upenn.edu

Affiliations Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Program in Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Epistasis
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Fitness epistasis
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Phylogenetics
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Phylogenetic analysis
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Substitution mutation
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Drug interactions
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Viral evolution
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Mutation detection
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