The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny

Andreas Rechtsteiner; Sevinc Ercan; Teruaki Takasaki; Taryn M. Phippen; Thea A. Egelhofer; Wenchao Wang; Hiroshi Kimura; Jason D. Lieb; Susan Strome

doi:10.1371/journal.pgen.1001091

Loading metrics

Open Access

Peer-reviewed

Research Article

The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny

Andreas Rechtsteiner ,

Contributed equally to this work with: Andreas Rechtsteiner, Sevinc Ercan, Teruaki Takasaki

Affiliation Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Sevinc Ercan ,

Contributed equally to this work with: Andreas Rechtsteiner, Sevinc Ercan, Teruaki Takasaki

Affiliation Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Teruaki Takasaki ,

Contributed equally to this work with: Andreas Rechtsteiner, Sevinc Ercan, Teruaki Takasaki

Affiliation Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Taryn M. Phippen,

Affiliation Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Thea A. Egelhofer,

Affiliation Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Wenchao Wang,

Current address: Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America

Affiliation Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯
Hiroshi Kimura,

Affiliation Graduate School for Frontier Biosciences, Osaka University, Suita, Osaka, Japan
⨯
Jason D. Lieb ,

* E-mail: strome@biology.ucsc.edu (SS); jlieb@bio.unc.edu (JDL)

Affiliation Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Susan Strome

* E-mail: strome@biology.ucsc.edu (SS); jlieb@bio.unc.edu (JDL)

Affiliation Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
⨯

The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny

Andreas Rechtsteiner,
Sevinc Ercan,
Teruaki Takasaki,
Taryn M. Phippen,
Thea A. Egelhofer,
Wenchao Wang,
Hiroshi Kimura,
Jason D. Lieb,
Susan Strome

Published: September 2, 2010
https://doi.org/10.1371/journal.pgen.1001091

Reader Comments

Post a new comment on this article

Additional acknowledgement

Posted by strome on 05 Sep 2010 at 15:38 GMT

We thank Jinkyo Suh, Hirofumi Furuhashi, and Bill Kelly for sharing unpublished results and Bill Kelly, Hirofumi Furuhashi, members of the Strome and Lieb labs, and other members of the modENCODE consortium for helpful discussions
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001091#article1.back1.ack1.p1

We thank A. Leo Iniguez and Heidi Rosenbaum at Roche NimbleGen for assistance performing ChIP-chip experiments.

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Embryos
Is the Subject Area "Embryos" applicable to this article?

Thanks for your feedback.
Methylation
Is the Subject Area "Methylation" applicable to this article?

Thanks for your feedback.
X chromosomes
Is the Subject Area "X chromosomes" applicable to this article?

Thanks for your feedback.
Autosomes
Is the Subject Area "Autosomes" applicable to this article?

Thanks for your feedback.
Chromatin
Is the Subject Area "Chromatin" applicable to this article?

Thanks for your feedback.
DNA transcription
Is the Subject Area "DNA transcription" applicable to this article?

Thanks for your feedback.
Histones
Is the Subject Area "Histones" applicable to this article?

Thanks for your feedback.

The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny

The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Additional acknowledgement

Posted by strome on 05 Sep 2010 at 15:38 GMT