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Very interesting addition

Posted by agonzalez1 on 13 Dec 2011 at 20:41 GMT

We observed that SLE shares the largest number of loci with RA (FAM167A/BLK, IRF5/TNP03, and STAT4). It is noteworthy that SLE appears isolated from the other ADs
http://plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002406#article1.body1.sec2.sec5.p3

This very exhaustive and nice work is a welcomed addition that puts limits to the sharing of genetic factors between different autoimmune diseases. This has been a so dominant theme that any result questioning it has been received with skepticism. This was the case with a work we did two years ago (http://www.ncbi.nlm.nih.gov/pubmed/19714582) that is now vindicated in this larger and more comprehensive study.

No competing interests declared.